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Anti-HDAC6 Antibody (CAB11261)

SKU:
CAB11261
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Autophagy
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-HDAC6 Antibody
Antibody SKU:CAB11261
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 836-1104 of human HDAC6 (NP_006035.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Mouse kidney, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 836-1104 of human HDAC6 (NP_006035.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VMKV EDRE GPSS SKLV TKKA PQPA KPRL AERM TTRE KKVL EAGM GKVT SASF GEES TPGQ TNSE TAVV ALTQ DQPS EAAT GGAT LAQT ISEA AIGG AMLG QTTS EEAV GGAT PDQT TSEE TVGG AILD QTTS EDAV GGAT LGQT TSEE AVGG ATLA QTTS EAAM EGAT LDQT TSEE APGG TELI QTPL ASST DHQT PPTS PVQG TTPQ ISPS TLIG SLRT LELG SESQ GASE SQAP GEEN LLGE AAGG QDMA DSML MQGS RGLT DQAI F
Gene ID:10013
Uniprot:Q9UBN7
Cellular Location:Cell projection, Cytoplasm, Nucleus, Perikaryon, axon, dendrite
Calculated MW:114kDa/131kDa
Observed MW:170kDa
Synonyms:HDAC6, CPBHM, HD6, JM21, PPP1R90
Background:Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
UniProt Protein Function:HDAC6: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; EC 3.5.1.98; Nuclear receptor co-regulator; Deacetylase

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: microtubule; dendrite; histone deacetylase complex; leading edge; perikaryon; caveola; inclusion body; cytosol; nucleoplasm; dynein complex; microtubule associated complex; axon; perinuclear region of cytoplasm; cytoplasmic microtubule; cytoplasm; nucleus

Molecular Function:zinc ion binding; microtubule binding; histone deacetylase binding; beta-catenin binding; beta-tubulin binding; Hsp90 protein binding; misfolded protein binding; actin binding; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); tubulin deacetylase activity; ubiquitin protein ligase binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; polyubiquitin binding; tau protein binding; alpha-tubulin binding

Biological Process: negative regulation of proteolysis; response to misfolded protein; protein polyubiquitination; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; positive regulation of signal transduction; regulation of fat cell differentiation; macroautophagy; negative regulation of microtubule depolymerization; response to toxin; organelle organization and biogenesis; misfolded or incompletely synthesized protein catabolic process; histone deacetylation; regulation of gene expression, epigenetic; response to organic substance; intracellular protein transport; protein complex disassembly; lysosome localization; protein amino acid deacetylation; negative regulation of oxidoreductase activity; regulation of receptor activity; negative regulation of transcription, DNA-dependent; negative regulation of protein complex disassembly

Disease: Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia

NCBI Summary:Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UBN7
NCBI GenInfo Identifier:205371758
NCBI Gene ID:10013
NCBI Accession:Q9UBN7.2
UniProt Secondary Accession:Q9UBN7,O94975, Q6NT75, Q7L3E5, Q96CY0,
UniProt Related Accession:Q9UBN7
Molecular Weight:114,361 Da
NCBI Full Name:Histone deacetylase 6
NCBI Synonym Full Names:histone deacetylase 6
NCBI Official Symbol:HDAC6  
NCBI Official Synonym Symbols:HD6; JM21; CPBHM; PPP1R90  
NCBI Protein Information:histone deacetylase 6; protein phosphatase 1, regulatory subunit 90
UniProt Protein Name:Histone deacetylase 6
UniProt Gene Name:HDAC6  
UniProt Entry Name:HDAC6_HUMAN
Anti-HDAC6 Antibody (CAB11261)Western blot analysis of extracts of various cell lines, using HDAC6 antibody (CAB11261) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

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