The HDAC6 Polyclonal Antibody (CAB11259) offered by Assay Genie is a valuable tool for researchers studying histone deacetylase 6 (HDAC6), a key enzyme involved in epigenetic regulation and cell signaling processes. Raised in rabbits, this antibody exhibits high reactivity with human samples and has been validated for use in Western blot applications.HDAC6 is known for its role in regulating gene expression, protein degradation, and cellular stress responses. Dysregulation of HDAC6 has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
By targeting the HDAC6 protein, researchers can explore its function and potential therapeutic applications in these disease contexts.This antibody enables specific detection and analysis of HDAC6 in a variety of cell types, making it a versatile tool for studies in molecular biology, cell biology, and drug discovery. With its ability to target HDAC6, researchers can uncover new insights into the role of this enzyme in disease pathology and develop novel treatment strategies that target HDAC6 activity.
Product Name:
HDAC6 Rabbit Polyclonal Antibody
SKU:
CAB11259
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 836-1104 of human HDAC6 (NP_006035.2).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Purification Method:
Affinity purification
Gene ID:
10013
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat liver, using HDAC6 Rabbit pAb (CAB11259) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
