The HDAC5 Polyclonal Antibody (CAB7189) is a valuable tool for researchers studying the role of HDAC5, a histone deacetylase implicated in gene regulation and cellular processes. This antibody, generated in rabbits, shows high specificity and reactivity with human samples, making it a reliable choice for Western blot applications. By targeting the HDAC5 protein, researchers can gain insights into its function and involvement in various cellular pathways.HDAC5 is known to play a pivotal role in epigenetic regulation, influencing gene expression and cell differentiation. Its dysregulation has been linked to diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions.
By studying the activity of HDAC5 using this antibody, researchers can unravel its molecular mechanisms and potential therapeutic targets for treating these diseases.This HDAC5 Polyclonal Antibody is a valuable asset for scientists working in fields such as molecular biology, oncology, and neuroscience. Its ability to specifically detect HDAC5 protein in different cell types paves the way for deeper insights into its biological functions and pathological roles. With this antibody, researchers can advance their understanding of HDAC5 and its implications in various disease settings.
Product Name:
HDAC5 Rabbit Polyclonal Antibody
SKU:
CAB7189
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human HDAC5 (NP_005465.2).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10014
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HDAC5 antibody (CAB7189) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
