The HDAC4 Rabbit Monoclonal Antibody is a powerful tool for researchers studying HDAC4, a histone deacetylase involved in gene regulation and cellular processes such as differentiation and apoptosis. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting HDAC4 in human samples, making it an ideal choice for Western blot and immunohistochemistry applications.HDAC4 is a key player in epigenetic regulation, influencing gene expression by modifying chromatin structure. Dysregulation of HDAC4 has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions.
By targeting HDAC4 with this antibody, researchers can gain valuable insights into its role in disease pathogenesis and potential therapeutic interventions.With its reliability and precision, the HDAC4 Rabbit Monoclonal Antibody is a valuable asset for scientists exploring the intricate mechanisms of HDAC4 in health and disease. Its ability to specifically detect HDAC4 protein expression in various cell types opens up new opportunities for advancements in molecular biology and drug discovery.
Product Name:
HDAC4 Rabbit Monoclonal Antibody
SKU:
CAB13510
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HDAC4 (P56524).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Purification Method:
Affinity purification
Gene ID:
9759
Clone Number:
ARC0714
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using HDAC4 antibody (CAB13510) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
