The HDAC4 Polyclonal Antibody (CAB0239) is a valuable tool for researchers studying the HDAC4 protein, a member of the histone deacetylase family involved in epigenetic regulation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to HDAC4, the antibody allows for accurate detection and analysis of this important protein in various cell types.HDAC4 is known to play a crucial role in gene expression, cell differentiation, and cell survival, making it a promising target for research in various fields, including cancer biology, neurology, and cardiovascular diseases.
Understanding the function and regulation of HDAC4 can provide insights into its potential role in disease pathology and help in the development of targeted therapies.Overall, the HDAC4 Polyclonal Antibody is a reliable tool for researchers looking to investigate the role of HDAC4 in cellular processes and disease mechanisms, paving the way for advancements in therapeutic strategies and personalized medicine.
Product Name:
HDAC4 Rabbit Polyclonal Antibody
SKU:
CAB0239
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 530-630 of human HDAC4 (NP_006028.2).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Purification Method:
Affinity purification
Gene ID:
9759
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using HDAC4 Rabbit pAb (CAB0239) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
