HDAC4 Rabbit Polyclonal Antibody (CAB0179)
- SKU:
- CAB0179
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | HDAC4 Rabbit Polyclonal Antibody |
SKU: | CAB0179 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 451-650 of human HDAC4 (NP_006028.2). |
Sequence: | PSIH KLRQ HRPL GRTQ SAPL PQNA QALQ HLVI QQQH QQFL EKHK QQFQ QQQL QMNK IIPK PSEP ARQP ESHP EETE EELR EHQA LLDE PYLD RLPG QKEA HAQA GVQV KQEP IESD EEEA EPPR EVEP GQRQ PSEQ ELLF RQQA LLLE QQRI HQLR NYQA SMEA AGIP VSFG GHRP LSRA QSSP ASAT FPVS VQEP PTKP |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:100 |
Synonyms: | HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; NEDCHF; NEDCHID; HDAC4 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 119kDa |
Observed MW: | 140kDa |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Purification Method: | Affinity purification |
Gene ID: | 9759 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |