The HDAC4 Polyclonal Antibody (CAB0179) is a valuable tool for researchers studying HDAC4, a protein involved in gene regulation and cellular processes. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the HDAC4 protein, allowing for precise detection and analysis in a variety of cell types.HDAC4, a histone deacetylase, plays a crucial role in the regulation of gene expression and has been implicated in various diseases, including cancer and neurodegenerative disorders.
By targeting HDAC4, researchers can gain insights into the mechanisms underlying these conditions and potentially develop new therapeutic strategies.The HDAC4 Polyclonal Antibody is a valuable tool for studying HDAC4 function and its role in disease pathogenesis. Its specificity and reliability make it an essential reagent for researchers in the fields of molecular biology, oncology, and neuroscience.
Product Name:
HDAC4 Rabbit Polyclonal Antibody
SKU:
CAB0179
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 451-650 of human HDAC4 (NP_006028.2).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Purification Method:
Affinity purification
Gene ID:
9759
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using HDAC4 Rabbit pAb (CAB0179) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC): U-2 OS.Exposure time: 60s.
