The HDAC3 Rabbit Monoclonal Antibody (CAB19537) is a cutting-edge tool for researchers studying histone deacetylase 3 (HDAC3), a crucial epigenetic regulator involved in gene expression and chromatin remodeling. This antibody, sourced from rabbits, is highly specific to HDAC3 and has been validated for use in a variety of applications, including Western blotting and immunofluorescence.HDAC3 plays a key role in diverse biological processes, such as cell proliferation, differentiation, and apoptosis, making it a target of interest in cancer research and developmental biology.
By targeting HDAC3 with this monoclonal antibody, researchers can investigate its functions in various cellular pathways and uncover potential therapeutic strategies.With its high reactivity and specificity, the HDAC3 Rabbit Monoclonal Antibody (CAB19537) is an invaluable tool for advancing our understanding of epigenetic regulation and its implications in various diseases. Researchers in fields such as oncology, neuroscience, and molecular biology will find this antibody essential for their studies on HDAC3 and its role in complex biological processes.
Product Name:
HDAC3 Rabbit Monoclonal Antibody
SKU:
CAB19537
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 329-428 of human HDAC3 (NP_003874.2).
WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
HD3; RPD3; KDAC3; RPD3-2; HDAC3
Positive Sample:
PC-3,HeLa,Mouse brain,NIH/3T3,Rat testis
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus, cytosol.
Calculated MW:
49kDa
Observed MW:
49kDa
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Purification Method:
Affinity purification
Gene ID:
8841
Clone Number:
ARC0016
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using HDAC3 Rabbit mAb (CAB19537) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1min.
