The HDAC3 Polyclonal Antibody (CAB2139) is a valuable tool for researchers studying HDAC3, a critical enzyme involved in gene regulation and epigenetic modification. This antibody, produced in rabbits, shows high specificity for human samples and has been validated for use in Western blot applications. It binds specifically to the HDAC3 protein, allowing for accurate detection and analysis in a variety of cell types.HDAC3, a member of the histone deacetylase family, is known to play a pivotal role in chromatin remodeling and gene expression. Dysregulation of HDAC3 has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes.
Therefore, studying the function and activity of HDAC3 is crucial for elucidating its role in disease progression and identifying potential therapeutic targets.By using the HDAC3 Polyclonal Antibody in research, scientists can gain valuable insights into the molecular mechanisms underlying HDAC3-mediated processes, paving the way for the development of novel treatment strategies. Whether investigating epigenetic modifications in cancer cells or exploring the role of HDAC3 in metabolic disorders, this antibody provides a reliable tool for advancing scientific understanding in these areas.
Product Name:
HDAC3 Rabbit Polyclonal Antibody
SKU:
CAB2139
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 299-428 of human HDAC3 (NP_003874.2).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Purification Method:
Affinity purification
Gene ID:
8841
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using HDAC3 Rabbit pAb (CAB2139) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
