HDAC3 Rabbit Polyclonal Antibody (CAB2139)
- SKU:
- CAB2139
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IF
- IP
- ChIP
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | HDAC3 Rabbit Polyclonal Antibody |
SKU: | CAB2139 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 299-428 of human HDAC3 (NP_003874.2). |
Sequence: | TVRN VARC WTYE TSLL VEEA ISEE LPYS EYFE YFAP DFTL HPDV STRI ENQN SRQY LDQI RQTI FENL KMLN HAPS VQIH DVPA DLLT YDRT DEAD AEER GPEE NYSR PEAP NEFY DGDH DNDK ESDV EI |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | HD3; RPD3; KDAC3; RPD3-2; HDAC3 |
Positive Sample: | HeLa,MCF7,NIH/3T3,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, cytosol. |
Calculated MW: | 49kDa |
Observed MW: | 49kDa |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Purification Method: | Affinity purification |
Gene ID: | 8841 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |