The HDAC3 Polyclonal Antibody (CAB16462) is a high-quality antibody designed for research involving HDAC3, a key player in epigenetic regulation. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the HDAC3 protein, this antibody enables accurate detection and analysis in various cell types, facilitating research in fields such as oncology and neuroscience.HDAC3, a member of the histone deacetylase family, regulates gene expression by removing acetyl groups from histones, leading to chromatin condensation and gene repression.
Dysregulation of HDAC3 has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic conditions. By studying the function of HDAC3, researchers can gain valuable insights into the underlying mechanisms of these diseases and potentially identify novel therapeutic targets.Overall, the HDAC3 Polyclonal Antibody (CAB16462) is a valuable tool for researchers interested in exploring the role of HDAC3 in health and disease. Its high specificity and reactivity make it a reliable choice for studying the epigenetic regulation of gene expression in various biological contexts.
Product Name:
HDAC3 Rabbit Polyclonal Antibody
SKU:
CAB16462
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 329-428 of human HDAC3 (NP_003874.2).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Purification Method:
Affinity purification
Gene ID:
8841
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HDAC3 Rabbit pAb (CAB16462) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
