The HDAC3 Polyclonal Antibody (CAB12542) is a powerful tool for research involving HDAC3, a key enzyme involved in the regulation of gene expression. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications. By binding specifically to the HDAC3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it a valuable asset for studies in epigenetics, cancer research, and drug development.HDAC3, a member of the histone deacetylase family, plays a crucial role in the modification of chromatin structure and gene transcription. Dysregulation of HDAC3 activity has been implicated in a range of diseases, including cancer, neurological disorders, and metabolic syndromes.
Research into the functions and mechanisms of HDAC3 could lead to the development of novel therapeutic approaches targeting epigenetic modifications and gene expression patterns.By utilizing the HDAC3 Polyclonal Antibody (CAB12542), researchers can gain valuable insights into the role of HDAC3 in various biological processes and disease pathways. This antibody offers reliable and specific detection of HDAC3 in experimental settings, helping to advance our understanding of epigenetic regulation and the potential for targeted therapies.
Product Name:
HDAC3 Rabbit Polyclonal Antibody
SKU:
CAB12542
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 329-428 of human HDAC3 (NP_003874.2).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Purification Method:
Affinity purification
Gene ID:
8841
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using HDAC3 Rabbit pAb (CAB12542) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
