The HCRTR2 Polyclonal Antibody (CAB3057) is a valuable tool for researchers studying the hypocretin receptor 2 (HCRTR2) protein, which plays a key role in the regulation of sleep and wakefulness. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications, including immunohistochemistry and flow cytometry.HCRTR2 is a G-protein coupled receptor expressed in the brain that mediates the effects of the neuropeptides hypocretin/orexin. Dysregulation of the HCRTR2 pathway has been implicated in sleep disorders, such as narcolepsy, as well as mood disorders and other neurological conditions.
By targeting this receptor with the CAB3057 antibody, researchers can investigate HCRTR2 expression and function in different cell types and tissues, providing insight into its role in sleep regulation and potential therapeutic interventions. Overall, the HCRTR2 Polyclonal Antibody (CAB3057) is a valuable tool for researchers interested in studying the HCRTR2 protein and its involvement in sleep-related disorders and neurological conditions. Its high specificity and sensitivity make it an ideal choice for exploring the molecular mechanisms underlying these complex biological processes.
Product Name:
HCRTR2 Rabbit Polyclonal Antibody
SKU:
CAB3057
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 380-444 of human HCRTR2 (NP_001517.2).
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.
Purification Method:
Affinity purification
Gene ID:
3062
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HCRTR2 antibody (CAB3057) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
