The HCN3 Polyclonal Antibody (PACO09689) is a valuable tool for researchers studying HCN3, a member of the hyperpolarization-activated cyclic nucleotide-gated ion channel family. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the HCN3 protein, this antibody enables the accurate detection and analysis of HCN3 expression in a variety of cell types, making it ideal for studies in neuroscience and cardiac research.HCN3 plays a crucial role in regulating neuronal excitability and pacemaker activity in the heart.
Dysregulation of HCN3 has been implicated in various neurological disorders and cardiac arrhythmias, making it a promising therapeutic target for these conditions. By gaining a deeper understanding of the functions of HCN3, researchers can potentially develop novel treatments for conditions such as epilepsy, Parkinson's disease, and heart rhythm disorders.Overall, the HCN3 Polyclonal Antibody is a valuable tool for researchers investigating the role of HCN3 in health and disease. Its high specificity and sensitivity make it an essential component of any study involving HCN3 expression and function.
Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.
UniProt Protein Details:
NCBI Summary:
This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
