The HCN1 Polyclonal Antibody (CAB17279) is a valuable tool for researchers studying HCN1, a hyperpolarization-activated cyclic nucleotide-gated ion channel involved in neuronal excitability and pacemaker activity. This antibody, developed in rabbits, exhibits high specificity and sensitivity for detecting HCN1 in human samples, making it ideal for use in Western blot applications.HCN1 plays a crucial role in regulating neuronal firing and rhythmic activity in the brain, making it a key target for understanding neurological disorders such as epilepsy, Parkinson's disease, and neuropathic pain.
By targeting HCN1, researchers can investigate the underlying mechanisms of these conditions and develop potential therapeutic interventions.The HCN1 Polyclonal Antibody offers researchers a reliable tool for studying the expression and function of HCN1 in various cell types and tissues, providing valuable insights into the role of this ion channel in neurological health and disease. Its application in neuroscience and pharmacology research makes it a valuable asset for advancing our understanding of neuronal excitability and potential drug targets for neurological disorders.
Product Name:
HCN1 Polyclonal Antibody
SKU:
CAB17279
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 791-890 of human HCN1 (NP_066550.2).
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes.
Purification Method:
Affinity purification
Gene ID:
348980
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HCN1 Rabbit pAb (CAB17279) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
