The HCN1 Polyclonal Antibody (CAB16198) is a valuable tool for research involving the HCN1 protein, a key player in neuronal excitability and pacemaking. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the HCN1 protein, this antibody enables accurate detection and analysis in various cell types, making it well-suited for studies in neuroscience and neurological disorders.HCN1 is a member of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel family, crucial for regulating neuronal firing rates and pacemaking activity in the brain.
Dysregulation of HCN1 has been implicated in various neurological conditions, including epilepsy, neuropathic pain, and Parkinson's disease. Investigating the function and expression of HCN1 is essential for understanding the mechanisms underlying these neurological disorders and developing targeted therapeutic interventions.Overall, the HCN1 Polyclonal Antibody (CAB16198) offers researchers a reliable tool for studying the role of HCN1 in neuronal excitability, pacemaking, and neurological disease pathophysiology. Its specificity and sensitivity make it an invaluable resource for advancing research in the field of neuroscience.
Product Name:
HCN1 Rabbit Polyclonal Antibody
SKU:
CAB16198
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 791-890 of human HCN1 (NP_066550.2).
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes.
Purification Method:
Affinity purification
Gene ID:
348980
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using HCN1 antibody (CAB16198) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
