HCAR3/HCAR2 Antibody (PACO05630)
- SKU:
- PACO05630
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
HCAR3/HCAR2 Antibody (PACO05630)
The HCAR3/HCAR2 Polyclonal Antibody (PACO05630) is a valuable tool for researchers studying the HCAR3 and HCAR2 receptors, which play important roles in immune regulation and metabolism. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. It binds to the HCAR3 and HCAR2 proteins, allowing for the detection and analysis of these receptors in various cell types.HCAR3 and HCAR2, also known as hydroxycarboxylic acid receptors, are G protein-coupled receptors that are involved in sensing and responding to metabolic signals in the body. They have been linked to various physiological processes, including glucose metabolism, immune cell function, and inflammation.
Research on these receptors is essential for understanding how they contribute to diseases such as metabolic disorders, immune-related conditions, and cancer.By using the HCAR3/HCAR2 Polyclonal Antibody in their studies, researchers can gain insight into the mechanisms underlying HCAR3 and HCAR2 signaling, potentially leading to the development of novel therapeutic strategies for managing a range of diseases. This antibody is a valuable tool for investigators interested in exploring the roles of these receptors in both normal physiology and pathological conditions.
| Antibody Name: | HCAR3/HCAR2 Antibody (PACO05630) |
| Antibody SKU: | PACO05630 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human HM74. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | HCAR3; GPR109B; HCA3; HM74B; NIACR2; Hydroxycarboxylic acid receptor 3; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; Niacin receptor 2; Nicotinic acid receptor 2; HCAR2; GPR109A; HCA2; |
| UniProt Protein Function: | GPR109B: Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cell junction; integral to plasma membrane; plasma membrane |
| UniProt Code: | P49019 |
| NCBI GenInfo Identifier: | 519668680 |
| NCBI Gene ID: | 8843 |
| NCBI Accession: | P49019.3 |
| UniProt Secondary Accession: | P49019,Q8NGE4, A8K4G5, B2R830, E9PI97, |
| UniProt Related Accession: | P49019 |
| Molecular Weight: | 44,478 Da |
| NCBI Full Name: | Hydroxycarboxylic acid receptor 3 |
| NCBI Synonym Full Names: | hydroxycarboxylic acid receptor 3 |
| NCBI Official Symbol: | HCAR3Â Â |
| NCBI Official Synonym Symbols: | HCA3; HM74; PUMAG; Puma-g; GPR109BÂ Â |
| NCBI Protein Information: | hydroxycarboxylic acid receptor 3 |
| UniProt Protein Name: | Hydroxycarboxylic acid receptor 3 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; Niacin receptor 2; Nicotinic acid receptor 2 |
| Protein Family: | Hydroxycarboxylic acid receptor |
| UniProt Gene Name: | HCAR3Â Â |
| UniProt Entry Name: | HCAR3_HUMAN |
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