The HBQ1 Polyclonal Antibody (PACO09681) is a valuable tool for researchers studying HBQ1, a protein associated with human blood group antigens and immune response. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the HBQ1 protein, this antibody enables researchers to detect and analyze HBQ1 in various cell types, making it ideal for studies in immunology and transfusion medicine.
HBQ1, also known as the Human Blood Group Antigen, is crucial for understanding blood compatibility and transfusion reactions. Its role in the immune response makes it a key player in diseases like hemolytic disease of the newborn and autoimmunity. By studying HBQ1, researchers can gain valuable insights into blood group antigen interactions and immune system function, paving the way for improved diagnostics and treatments in the field of transfusion medicine.
HBQ1: Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: hemoglobin complexMolecular Function: iron ion binding; heme binding; oxygen binding; oxygen transporter activityBiological Process: oxygen transport
UniProt Protein Details:
NCBI Summary:
Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]