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Anti-HBD Antibody (CAB9220)

SKU:
CAB9220
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-HBD Antibody
Antibody SKU:CAB9220
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human HBD (NP_000510.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse lung, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human HBD (NP_000510.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVHL TPEE KTAV NALW GKVN VDAV GGEA LGRL LVVY PWTQ RFFE SFGD LSSP DAVM GNPK VKAH GKKV LGAF SDGL AHLD NLKG TFSQ LSEL HCDK LHVD PENF RLLG NVLV CVLA RNFG KEFT PQMQ AAYQ KVVA GVAN ALAH KYH
Gene ID:3045
Uniprot:P02042
Cellular Location:
Calculated MW:16kDa
Observed MW:13kDa
Synonyms:HBD
Background:The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia.
UniProt Protein Function:HBD: Involved in oxygen transport from the lung to the various peripheral tissues. Belongs to the globin family.
UniProt Protein Details:

Protein type:Carrier

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: hemoglobin complex; cytosol

Molecular Function:iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: oxygen transport; blood coagulation

NCBI Summary:The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. [provided by RefSeq, Jul 2008]
UniProt Code:P02042
NCBI GenInfo Identifier:4504351
NCBI Gene ID:3045
NCBI Accession:NP_000510.1
UniProt Secondary Accession:P02042,Q3Y5H3, Q8WXT7,
UniProt Related Accession:P02042
Molecular Weight:
NCBI Full Name:hemoglobin subunit delta
NCBI Synonym Full Names:hemoglobin, delta
NCBI Official Symbol:HBD  
NCBI Protein Information:hemoglobin subunit delta; delta globin; delta-globin chain; hemoglobin delta chain
UniProt Protein Name:Hemoglobin subunit delta
UniProt Synonym Protein Names:Delta-globin; Hemoglobin delta chain
Protein Family:Hemoglobin
UniProt Gene Name:HBD  
UniProt Entry Name:HBD_HUMAN
Anti-HBD Polyclonal Antibody (CAB9220)Western blot analysis of extracts of various cell lines, using HBD antibody (CAB9220) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

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