TIM-3/HAVCR2 Rabbit Polyclonal Antibody (CAB13445)
- SKU:
- CAB13445
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | TIM-3/HAVCR2 Rabbit Polyclonal Antibody |
SKU: | CAB13445 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-202 of human TIM-3/HAVCR2 (NP_116171.3). |
Sequence: | SEVE YRAE VGQN AYLP CFYT PAAP GNLV PVCW GKGA CPVF ECGN VVLR TDER DVNY WTSR YWLN GDFR KGDV SLTI ENVT LADS GIYC CRIQ IPGI MNDE KFNL KLVI KPAK VTPA PTRQ RDFT AAFP RMLT TRGH GPAE TQTL GSLP DINL TQIS TLAN ELRD SRLA NDLR DSGA TIRI G |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2; TIM-3/HAVCR2 |
Positive Sample: | THP-1,Mouse spleen,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 33kDa |
Observed MW: | 50kDa |
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
Purification Method: | Affinity purification |
Gene ID: | 84868 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |