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Anti-TIM-3/HAVCR2 Antibody (CAB13443)

SKU:
CAB13443
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 1 Anti-TIM-3/HAVCR2 Antibody CAB13443
  • Immunology Antibodies 1 Anti-TIM-3/HAVCR2 Antibody CAB13443
€139 - €419
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Description

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Anti-TIM-3/HAVCR2 Antibody (CAB13443)

The Havcr2 Polyclonal Antibody (CAB13443) is a research tool designed for scientists studying the Havcr2 protein, also known as Kidney Injury Molecule-1 (KIM-1). This cell surface molecule is implicated in kidney injury and repair processes, making it a crucial target for research in nephrology and renal disease.Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Havcr2 protein, researchers can accurately detect and analyze its expression in various cell types, providing valuable insights into kidney function and disease progression.

The Havcr2 Polyclonal Antibody is essential for studies investigating the role of Havcr2 in kidney injury, acute kidney damage, and chronic kidney disease. Its ability to target this specific protein makes it a valuable tool for understanding the molecular mechanisms underlying kidney-related pathologies and developing targeted therapies to improve patient outcomes.

Antibody Name:Anti-TIM-3/HAVCR2 Antibody
Antibody SKU:CAB13443
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIM-3/HAVCR2 (NP_116171.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse spleen, Raji
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIM-3/HAVCR2 (NP_116171.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MFSH LPFD CVLL LLLL LLTR SSEV EYRA EVGQ NAYL PCFY TPAA PGNL VPVC WGKG ACPV FECG NVVL RTDE RDVN YWTS RYWL NGDF RKGD VSLT IENV
Gene ID:84868
Uniprot:Q8TDQ0
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:85kDa/100kDa/105kDa/106kDa
Observed MW:45kDa/70kDa
Synonyms:HAVCR2, CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3
Background:The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
UniProt Protein Function:TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: integral to membrane

Disease: Rheumatoid Arthritis

NCBI Summary:The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
UniProt Code:Q8TDQ0
NCBI GenInfo Identifier:311033536
NCBI Gene ID:84868
NCBI Accession:Q8TDQ0.3
UniProt Related Accession:Q8TDQ0
Molecular Weight:
NCBI Full Name:Hepatitis A virus cellular receptor 2
NCBI Synonym Full Names:hepatitis A virus cellular receptor 2
NCBI Official Symbol:HAVCR2  
NCBI Official Synonym Symbols:TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2  
NCBI Protein Information:hepatitis A virus cellular receptor 2
UniProt Protein Name:Hepatitis A virus cellular receptor 2
UniProt Synonym Protein Names:T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3
UniProt Gene Name:HAVCR2  
UniProt Entry Name:HAVR2_HUMAN
Anti-TIM-3/HAVCR2 Antibody (CAB13443)Western blot analysis of extracts of various cell lines, using TIM-3/HAVCR2 antibody (CAB13443) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-TIM-3/HAVCR2 Antibody (CAB13443)Immunofluorescence analysis of Hela cells using TIM-3/HAVCR2 antibody (CAB13443) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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