The HAUSP (USP7) Rabbit Monoclonal Antibody (CAB3448) is a high-quality antibody designed for research involving HAUSP/USP7, a deubiquitinating enzyme that plays a crucial role in regulating the stability and activity of numerous proteins involved in cell cycle progression, DNA damage response, and tumor suppression.Raised in rabbits, this antibody is highly specific and reactive with human samples, making it an ideal tool for studying the function of HAUSP/USP7 in various cellular processes. Validated for use in Western blot applications, this antibody binds specifically to the HAUSP/USP7 protein, enabling accurate detection and analysis in different cell types.
The HAUSP/USP7 protein is known for its involvement in various cellular pathways, including p53 regulation, DNA repair, and chromatin remodeling. Dysregulation of HAUSP/USP7 has been implicated in cancer development and progression, making it a promising target for cancer research and drug development.By utilizing the HAUSP (USP7) Rabbit Monoclonal Antibody (CAB3448) in your research, you can gain valuable insights into the role of HAUSP/USP7 in cellular processes and disease pathogenesis, paving the way for the development of novel therapeutic strategies targeting this important protein.
Product Name:
USP7/HAUSP Rabbit Monoclonal Antibody
SKU:
CAB3448
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human USP7/HAUSP (Q93009).
The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder.
Purification Method:
Affinity purification
Gene ID:
7874
Clone Number:
ARC0777
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using USP7/HAUSP Rabbit mAb (CAB3448) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
