The HAUS7 Antibody (PAC020813) is a cutting-edge tool for researchers studying the HAUS7 protein, an essential component of the Augmin complex involved in microtubule generation and mitotic spindle assembly. This polyclonal antibody, produced through rabbit immunization, is highly specific to human samples and suitable for use in Western blot applications. By targeting the HAUS7 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an invaluable resource for studies in cell biology and cancer research.HAUS7, a key player in the regulation of microtubule dynamics during cell division, is crucial for ensuring the accurate segregation of chromosomes and maintenance of genomic stability.
Dysregulation of HAUS7 function has been implicated in various diseases, including cancer and developmental disorders. By elucidating the role of HAUS7 in cellular processes, researchers can uncover potential therapeutic targets for the treatment of these conditions.Overall, the HAUS7 Antibody (PAC020813) provides researchers with a reliable tool for investigating the function of the HAUS7 protein and its implications in disease pathology. Its high specificity and sensitivity make it an ideal choice for experiments exploring the molecular mechanisms underlying cell division and potential therapeutic interventions.
Antibody Name:
HAUS7 Antibody (PACO20813)
Antibody SKU:
PACO20813
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human HAUS7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20813(HAUS7 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants.
Synonyms:
HAUS augmin-like complex, subunit 7
UniProt Protein Function:
HAUS7: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Belongs to the HAUS7 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Deoxyribonuclease; DNA-binding; EC 3.1.11.2Chromosomal Location of Human Ortholog: Xq28Cellular Component: centrosome; cytoplasm; cytosol; nucleolus; plasma membraneMolecular Function: thioesterase bindingBiological Process: centrosome organization and biogenesis; G2/M transition of mitotic cell cycle; spindle assembly
UniProt Protein Details:
NCBI Summary:
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
