The HAUS6 Polyclonal Antibody (CAB4797) is specifically designed for research involving the HAUS6 protein, a component of the Augmin complex essential for mitotic spindle assembly. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in various applications including Western blotting. By specifically binding to the HAUS6 protein, this antibody allows for precise detection and analysis in different cell types, making it an ideal tool for studying cell division and mitosis in the fields of cell biology and cancer research.
The HAUS6 protein is a crucial player in the process of mitosis, as it participates in the formation of the mitotic spindle necessary for accurate chromosome segregation during cell division. Dysregulation of HAUS6 function has been linked to defects in cell proliferation and mitotic errors, which can contribute to the development of diseases such as cancer. Research focused on understanding the role of HAUS6 in mitosis can provide valuable insights into the mechanisms underlying cell division and may offer potential targets for therapeutic interventions in cancer treatment.
Product Name:
HAUS6 Rabbit Polyclonal Antibody
SKU:
CAB4797
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 676-955 of human HAUS6 (NP_060115.3).
Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle.
Calculated MW:
109kDa
Observed MW:
109kDa
The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Purification Method:
Affinity purification
Gene ID:
54801
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HAUS6 antibody (CAB4797) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
