The HAS2 Polyclonal Antibody (CAB9897) is a powerful tool for researchers studying hyaluronan synthase 2 (HAS2), an enzyme responsible for producing hyaluronic acid (HA) in the body. This antibody, raised in rabbits, is highly specific and reacts strongly with human samples. It has been validated for use in Western blot applications, allowing for the detection and analysis of HAS2 protein levels in various cell types.HAS2 plays a critical role in multiple physiological processes, including tissue hydration, wound healing, and inflammation. Dysregulation of HAS2 has been implicated in various diseases, such as cancer, arthritis, and heart disease.
By targeting HAS2 with this antibody, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for drug development.Overall, the HAS2 Polyclonal Antibody (CAB9897) is a valuable tool for scientists interested in studying the role of HAS2 in health and disease. Its high specificity and sensitivity make it ideal for use in immunology, oncology, and regenerative medicine research projects.
Product Name:
HAS2 Rabbit Polyclonal Antibody
SKU:
CAB9897
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 67-186 of human HAS2 (NP_005319.1).
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
Purification Method:
Affinity purification
Gene ID:
3037
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using HAS2 Rabbit pAb (CAB9897) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
