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Has2 Antibody (PACO27305)

SKU:
PACO27305
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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Has2 Antibody (PACO27305)

The HAS2 Polyclonal Antibody (PAC027305) is a valuable tool for research involving HAS2, an important enzyme involved in the synthesis of hyaluronic acid. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the HAS2 protein, this antibody enables researchers to study the expression and function of HAS2 in various cell types, making it ideal for studies in the fields of cell biology, biochemistry, and regenerative medicine.HAS2 is a critical enzyme involved in the production of hyaluronic acid, a major component of the extracellular matrix that plays a key role in cell migration, proliferation, and tissue repair.

Dysregulation of HAS2 expression has been implicated in various pathological conditions, including cancer, inflammation, and fibrosis. By studying the function of HAS2 using this antibody, researchers can gain insights into the mechanisms underlying these diseases and potentially develop novel therapeutic strategies targeting HAS2.Overall, the HAS2 Polyclonal Antibody (PAC027305) is a valuable tool for researchers studying the role of HAS2 in health and disease. Its high specificity and sensitivity make it an ideal choice for investigating the functions of HAS2 in various biological processes, providing valuable insights that may lead to the development of new treatments for a range of conditions.

Antibody Name:Has2 Antibody (PACO27305)
Antibody SKU:PACO27305
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Hyaluronan synthase 2 protein (67-374AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix.
Synonyms:Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid, synthase 2) (HA synthase 2), Has2
UniProt Protein Function:HAS2: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Expressed in fibroblasts. Belongs to the nodC/HAS family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; EC 2.4.1.212; Transferase

Cellular Component: cytoplasm; integral to membrane; integral to plasma membrane; membrane

Molecular Function:hyaluronan synthase activity; transferase activity; transferase activity, transferring glycosyl groups

Biological Process: cell adhesion; extracellular polysaccharide biosynthetic process; hyaluronan biosynthetic process; hyaluronan metabolic process; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of keratinocyte migration; positive regulation of smooth muscle cell migration; vasculogenesis

UniProt Code:P70312
NCBI GenInfo Identifier:
NCBI Gene ID:15117
NCBI Accession:NP_032242.3
UniProt Secondary Accession:P70312,P70411, Q62405, Q68EF7,
UniProt Related Accession:P70312
Molecular Weight:37.9 kDa
NCBI Full Name:
NCBI Synonym Full Names:hyaluronan synthase 2
NCBI Official Symbol:Has2  
NCBI Protein Information:hyaluronan synthase 2
UniProt Protein Name:Hyaluronan synthase 2
UniProt Synonym Protein Names:Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2
Protein Family:Hyaluronan synthase
UniProt Gene Name:Has2  
UniProt Entry Name:HYAS2_MOUSE

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