HAP1 Rabbit Polyclonal Antibody (CAB16333)
- SKU:
- CAB16333
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
Product Name: | HAP1 Rabbit Polyclonal Antibody |
SKU: | CAB16333 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HAP1 (NP_817084.2). |
Sequence: | MRPK RLGR CCAG SRLG PGDP AALT CAPS PSAS PAPE PSAQ PQAR GTGQ RVGS RATS GSQF LSEA RTGA RPAS EAGA KAGA RRPS AFSA IQGD VRSM PDNS DAPW TRFV FQGP FGSR ATGR GTGK AAGI WKTP AAYV GRRP GVSG PERA AFIR ELEE ALCP NLPP PVKK ITQE DVKV MLYL LEEL LPPV WESV TYGM VLQR ERDL NTAA RIGQ SLVK QNSV LMEE NSKL EALL GSAK EEIL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | HLP; HAP2; HIP5; hHLP1; HAP1 |
Positive Sample: | Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | actin cytoskeleton, autophagosome, axon cytoplasm, centriole, centrosome, cytoplasmic vesicle, cytoskeleton, cytosol, dendrite, dendritic spine, early endosome, endoplasmic reticulum, growth cone, lysosome, mitochondrion, nucleolus, synaptic vesicle |
Calculated MW: | 76kDa |
Observed MW: | 76kDa |
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 9001 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |