The HAND2 Polyclonal Antibody (CAB7044) is a valuable tool for researchers studying HAND2, a transcription factor critical for heart development and function. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the HAND2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in cardiovascular biology and developmental biology.HAND2, also known as heart- and neural crest derivatives-expressed protein 2, plays a crucial role in the formation of the heart and other tissues during embryonic development.
Its importance in cardiac development and function makes HAND2 a key target for research into congenital heart defects, cardiomyopathies, and other cardiovascular disorders. Understanding the mechanisms by which HAND2 regulates gene expression and cell differentiation is essential for developing new therapies for heart disease and other related conditions.
Product Name:
HAND2 Rabbit Polyclonal Antibody
SKU:
CAB7044
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 151-217 of human HAND2 (NP_068808.1).
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
Purification Method:
Affinity purification
Gene ID:
9464
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HAND2 antibody (CAB7044) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
