The Hamartin Polyclonal Antibody (CAB0720) offered by AssayGenie is a vital tool for researchers studying TSC1 protein, also known as Hamartin. This antibody, produced through polyclonal technology, exhibits high specificity and reactivity with human samples. Validated for use in Western blot applications, the CAB0720 antibody facilitates the detection and analysis of the TSC1 protein in various cell types.TSC1, a tumor suppressor protein, is implicated in various cellular processes, including cell growth and proliferation. Dysregulation of TSC1 has been linked to diseases such as tuberous sclerosis complex (TSC) and certain cancers.
Research on TSC1 is essential for advancing our understanding of these conditions and developing targeted therapies.By using the Hamartin Polyclonal Antibody (CAB0720), researchers can uncover the role of TSC1 in disease development and progression, ultimately paving the way for innovative treatments and interventions. Get your hands on this high-quality antibody from AssayGenie today and accelerate your research in the field of cancer and genetic disorders.
Product Name:
TSC1 Rabbit Polyclonal Antibody
SKU:
CAB0720
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human TSC1 (NP_000359.1).
Sequence:
QPPP YDHL FEVA LPKT AHHF VIRK TEEL LKKA KGNT EEDG VPST SPME VLDR LIQQ GADA HSKE LNKL PLPS KSVD WTHF GGSP PSDE IRTL RDQL LLLH N
This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including TSC2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.
Purification Method:
Affinity purification
Gene ID:
7248
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat spleen, using TSC1 Rabbit pAb (CAB0720) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
