The HACE1 Polyclonal Antibody (CAB9593) is a valuable tool for researchers studying the HACE1 protein. HACE1 is a HECT domain-containing E3 ubiquitin ligase that plays a role in ubiquitin-mediated protein degradation and is involved in various cellular processes, including cell cycle regulation and tumor suppression. This polyclonal antibody, produced in rabbits, is highly specific to human HACE1 and has been validated for use in Western blotting applications. By binding to HACE1, this antibody allows for the detection and analysis of HACE1 protein levels in different cell types, making it ideal for studies in cancer research and cellular biology.
Understanding the function of HACE1 is crucial for uncovering its role in tumorigenesis and exploring its potential as a therapeutic target in cancer treatment. By using the HACE1 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying HACE1-mediated protein degradation and its implications for cellular homeostasis and disease development.
Product Name:
HACE1 Rabbit Polyclonal Antibody
SKU:
CAB9593
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HACE1 (NP_065822.2).
This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor.
Purification Method:
Affinity purification
Gene ID:
57531
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HACE1 Rabbit pAb (CAB9593) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
