H3F3C Antibody (PACO14509)
- SKU:
- PACO14509
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
H3F3C Antibody (PACO14509)
The H3F3C Monoclonal Antibody (PACO14509) is specifically designed for research targeting the H3F3C protein, a key player in epigenetic regulation and chromatin remodeling processes. This antibody, produced through hybridoma technology, exhibits high specificity and sensitivity for detecting H3F3C in a variety of samples, making it a valuable tool for researchers studying gene expression, DNA repair, and cell differentiation.H3F3C is a histone variant that plays a crucial role in maintaining chromatin structure and regulating gene transcription.
Dysregulation of H3F3C has been linked to various diseases, including cancer and neurodevelopmental disorders, highlighting its importance in cellular function. By utilizing the PACO14509 antibody, researchers can investigate the role of H3F3C in these pathological conditions and potentially identify novel therapeutic targets for intervention.
| Antibody Name: | H3F3C Antibody (PACO14509) |
| Antibody SKU: | PACO14509 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human H3F3C |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 12%SDS-PAGE, Lysate: 20 μg, Lane 1-2: Human fetal brain tissue, Hela cells, Primary antibody: PACO14509(H3F3C Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
| Background: | Eukaryotic histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene, that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. |
| Synonyms: | H3 histone, family 3C |
| UniProt Protein Function: | H3: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H3 family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p22.2Cellular Component: nucleoplasm; nuclear chromosome; protein complex; membrane; extracellular region; nucleosome; nucleusMolecular Function: protein binding; DNA binding; histone binding; protein heterodimerization activityBiological Process: chromatin silencing at rDNA; nucleosome assembly; establishment and/or maintenance of chromatin architecture; negative regulation of gene expression, epigenetic; protein heterotetramerization; gene expression; blood coagulation; regulation of gene expression, epigenetic; DNA replication-dependent nucleosome assembly; DNA methylation on cytosine |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6NXT2 |
| NCBI GenInfo Identifier: | 4504281 |
| NCBI Gene ID: | |
| NCBI Accession: | NP_003520.1 |
| UniProt Secondary Accession: | Q6NXT2,P84243, Q16695, Q6NXT2, Q71DI3, P84244, P84245 |
| UniProt Related Accession: | Q6NXT2 |
| Molecular Weight: | 15kDa |
| NCBI Full Name: | histone H3.1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Histone H3.1 |
| UniProt Synonym Protein Names: | Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST1H3AÂ Â |
| UniProt Entry Name: | H31_HUMAN |
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