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H2AFY2 Antibody (PACO42014)

SKU:
PACO42014
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407

Description

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H2AFY2 Antibody (PACO42014)

The H2AFY2 Polyclonal Antibody (PAC042014) is a valuable tool for researchers studying the H2AFY2 protein, a histone variant involved in gene regulation and chromatin remodeling. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By targeting the H2AFY2 protein, researchers can visualize and analyze its expression in various cell types, making it a versatile tool for studies in epigenetics and cancer research.

H2AFY2, also known as macroH2A.2, is a key player in transcriptional regulation and chromatin structure, influencing processes like DNA repair and stem cell differentiation. Its role in gene expression modulation makes it a promising target for investigations into diseases such as cancer, developmental disorders, and aging-related conditions. Understanding the functions of H2AFY2 is essential for developing targeted therapies that manipulate gene expression for therapeutic benefit.

Antibody Name:H2AFY2 Antibody (PACO42014)
Antibody SKU:PACO42014
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Core histone macro-H2A.2 protein (1-260AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Synonyms:Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2), H2AFY2, MACROH2A2
UniProt Protein Function:H2AFY2: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: Barr body; ESC/E(Z) complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm

Molecular Function:chromatin DNA binding

Biological Process: brain development; chromatin silencing; dosage compensation; negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; positive regulation of keratinocyte differentiation; regulation of cell growth

NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015]
UniProt Code:Q9P0M6
NCBI GenInfo Identifier:12585260
NCBI Gene ID:55506
NCBI Accession:Q9P0M6.3
UniProt Secondary Accession:Q9P0M6,Q5SQT2,
UniProt Related Accession:Q9P0M6
Molecular Weight:40,058 Da
NCBI Full Name:Core histone macro-H2A.2
NCBI Synonym Full Names:H2A histone family member Y2
NCBI Official Symbol:H2AFY2  
NCBI Official Synonym Symbols:macroH2A2  
NCBI Protein Information:core histone macro-H2A.2
UniProt Protein Name:Core histone macro-H2A.2
Protein Family:Core histone macro
UniProt Gene Name:H2AFY2  
UniProt Entry Name:H2AW_HUMAN

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