The H2-AA Polyclonal Antibody (CAB18325) is a valuable tool for researchers studying H2-AA, a key molecule involved in antigen presentation and immune response regulation. This rabbit-derived antibody boasts high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the H2-AA protein, researchers can confidently detect and analyze its expression in various cell types, making it an essential tool for studies in immunology and infectious disease research.H2-AA is a critical component of the major histocompatibility complex (MHC) class II molecule, playing a crucial role in presenting antigens to T cells and eliciting immune responses.
Understanding the function and regulation of H2-AA is essential for gaining insights into immune activation, tolerance, and autoimmune diseases. The H2-AA Polyclonal Antibody provides researchers with a reliable means of studying H2-AA expression and localization, offering new avenues for investigating immune-mediated diseases and developing targeted therapies.
Product Name:
H2-Aa Rabbit Polyclonal Antibody
SKU:
CAB18325
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 27-208 of mouse H2-Aa (NP_034508.2).
external side of plasma membrane, lysosome, plasma membrane
Calculated MW:
28kDa
Observed MW:
28kDa
Enables peptide antigen binding activity. Involved in response to interferon-gamma. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and positive regulation of T cell differentiation. Located in external side of plasma membrane and lysosome. Part of MHC class II protein complex. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); glomerulonephritis (multiple); hematologic cancer (multiple); and systemic scleroderma (multiple). Orthologous to several human genes including HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1).
Purification Method:
Affinity purification
Gene ID:
14960
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using H2-Aa Rabbit pAb (CAB18325) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
