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GZMM Antibody (PACO09656)

SKU:
PACO09656
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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GZMM Antibody (PACO09656)

The GZMM Antibody (PACO09656) is a highly specific and sensitive tool for studying GZMM, a key protease enzyme involved in immune and inflammatory responses. This polyclonal antibody is raised in rabbits and is validated for use in various applications, including Western blotting and immunofluorescence.GZMM, also known as granzyme M, is primarily expressed in cytotoxic lymphocytes and plays a crucial role in immune surveillance and defense against pathogens and tumor cells. Its overexpression has been linked to certain inflammatory diseases and cancer progression.

The GZMM Antibody enables researchers to detect and analyze GZMM protein levels in different cell types, providing valuable insights into its biological functions and potential therapeutic applications.By targeting GZMM, researchers can further unravel the complex mechanisms involved in immune regulation, inflammation, and cancer development. The GZMM Antibody is a valuable tool for studies in immunology, oncology, and inflammatory diseases, offering new opportunities for advancing our understanding of these conditions and developing novel treatment strategies.

Antibody Name:GZMM Antibody (PACO09656)
Antibody SKU:PACO09656
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human GZMM
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:granzyme M (lymphocyte met-ase 1);GZMM;LMET1;MET1 ;
UniProt Protein Function:GZMM: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. Belongs to the peptidase S1 family. Granzyme subfamily.
UniProt Protein Details:

Protein type:Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: membrane

Molecular Function:protein binding; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: cell death

NCBI Summary:Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Code:P51124
NCBI GenInfo Identifier:296434527
NCBI Gene ID:3004
NCBI Accession:P51124.2
UniProt Related Accession:P51124
Molecular Weight:27,545 Da
NCBI Full Name:Granzyme M
NCBI Synonym Full Names:granzyme M
NCBI Official Symbol:GZMM  
NCBI Official Synonym Symbols:MET1; LMET1  
NCBI Protein Information:granzyme M
UniProt Protein Name:Granzyme M
UniProt Synonym Protein Names:Met-1 serine protease; Hu-Met-1; Met-ase; Natural killer cell granular protease
Protein Family:Granzyme
UniProt Gene Name:GZMM  
UniProt Entry Name:GRAM_HUMAN

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