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GZMB/GZMH Antibody (PACO02806)

SKU:
PACO02806
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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GZMB/GZMH Antibody (PACO02806)

The GZMB/GZMH Antibody (PACO02806) is a valuable tool for researchers studying the granzyme B (GZMB) and granzyme H (GZMH) proteins, which are key components of the immune system's cytotoxic response to infected or cancerous cells. This polyclonal antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. Granzymes are serine proteases that are released by cytotoxic T cells and natural killer cells to induce programmed cell death in target cells. GZMB and GZMH in particular play crucial roles in immune surveillance and defense against viral infections and cancer.

The PACO02806 antibody binds specifically to GZMB and GZMH, allowing for precise detection and analysis in a variety of cell types.Understanding the expression and function of GZMB and GZMH is essential for unraveling the mechanisms of immune-mediated cytotoxicity and developing targeted therapies for cancer and viral diseases. The GZMB/GZMH Antibody (PACO02806) offers researchers a reliable tool for investigating the role of these important proteins in immunology and cancer research.

Antibody Name:GZMB/GZMH Antibody
Antibody SKU:PACO02806
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the N-terminal region of human Granzyme B/H.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:GZMB; CGL1; CSPB; CTLA1; GRB; Granzyme B; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E; GZMH; C
UniProt Protein Function:GZMB: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes. Inactivated by the serine protease inhibitor diisopropylfluorophosphate. Belongs to the peptidase S1 family. Granzyme subfamily.
UniProt Protein Details:

Protein type:Apoptosis; EC 3.4.21.79; Protease

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: cytoplasm; cytosol; immunological synapse; intracellular membrane-bound organelle; membrane; nucleus

Molecular Function:protein binding; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: apoptosis; natural killer cell mediated cytotoxicity; protein processing

NCBI Summary:This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
UniProt Code:P10144
NCBI GenInfo Identifier:317373361
NCBI Gene ID:3002
NCBI Accession:P10144.2
UniProt Secondary Accession:P10144,Q8N1D2, Q9UCC1,
UniProt Related Accession:P10144
Molecular Weight:
NCBI Full Name:Granzyme B
NCBI Synonym Full Names:granzyme B
NCBI Official Symbol:GZMB  
NCBI Official Synonym Symbols:C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1  
NCBI Protein Information:granzyme B
UniProt Protein Name:Granzyme B
UniProt Synonym Protein Names:C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E
Protein Family:Granzyme
UniProt Gene Name:GZMB  

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