The GYG2 Polyclonal Antibody (PACO09651) is a valuable tool for researchers studying GYG2, a protein involved in glycogen metabolism. This antibody, produced in rabbits, is highly specific for detecting GYG2 in human samples and is validated for use in applications like Western blotting. By binding to the GYG2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for studies in biochemistry and metabolic research.
GYG2 is an enzyme that plays a crucial role in glycogen breakdown, a fundamental process in energy metabolism. Dysregulation of glycogen metabolism is implicated in various metabolic disorders, making GYG2 an important target for study in diseases like diabetes and metabolic syndrome. Understanding the function of GYG2 can provide insights into these conditions and potentially lead to the development of targeted therapies for improving metabolic health.
GYG2: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Belongs to the glycosyltransferase 8 family. Glycogenin subfamily. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear envelope; EC 2.4.1.186; Transferase; MitochondrialChromosomal Location of Human Ortholog: Xp22.3Cellular Component: cytosol; lysosomal lumenMolecular Function: glycogenin glucosyltransferase activityBiological Process: glycogen biosynthetic process; glycogen catabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]
