The GUF1 Antibody (PACO04929) offered by AssayGenie is a premium product designed for researchers studying the GUF1 protein, a key player in mitochondrial translation. This polyclonal antibody is raised in rabbits and has been extensively validated for use in Western blot applications, ensuring reliable and consistent results. GUF1 is a conserved protein involved in the regulation of mitochondrial ribosome assembly and translation, making it essential for proper mitochondrial function. Dysfunction of GUF1 has been linked to various mitochondrial disorders and has implications in diseases such as Parkinson's and Alzheimer's.
This antibody binds specifically to the GUF1 protein, allowing for accurate detection and analysis in a variety of cell types. Its high reactivity with human samples makes it an ideal tool for researchers in the fields of molecular biology, biochemistry, and genetics who are investigating mitochondrial translation and its role in human health and disease.By utilizing the GUF1 Antibody from AssayGenie, researchers can gain valuable insights into the function of GUF1 and its impact on mitochondrial biology, potentially leading to the development of novel therapeutic strategies for mitochondrial-related disorders.
Antibody Name:
GUF1 Antibody
Antibody SKU:
PACO04929
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human GUF1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
GUF1: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Belongs to the GTP-binding elongation factor family. LepA subfamily.Protein type: Mitochondrial; EC 3.6.5.-Chromosomal Location of Human Ortholog: 4p12Cellular Component: mitochondrial matrix; mitochondrial inner membraneMolecular Function: GTPase activity; GTP binding; ribosome bindingBiological Process: positive regulation of translation; translation
