The GUCY2F Polyclonal Antibody (CAB14242) is a valuable tool for researchers studying GUCY2F, a key enzyme involved in the synthesis of cyclic GMP, a crucial secondary messenger in numerous signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.GUCY2F plays a critical role in regulating vascular smooth muscle relaxation, platelet aggregation, neurotransmission, and other physiological processes. Dysregulation of GUCY2F has been implicated in various cardiovascular and neurological disorders, making it a promising target for therapeutic intervention.
By binding specifically to the GUCY2F protein, this antibody enables precise detection and analysis in a variety of cell types, making it a valuable tool for researchers investigating the function and regulation of GUCY2F in health and disease. Studies utilizing this antibody may contribute to the development of novel treatments for conditions where GUCY2F dysregulation is a contributing factor.
Product Name:
GUCY2F Rabbit Polyclonal Antibody
SKU:
CAB14242
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-460 of human GUCY2F (NP_001513.2).
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa.
Purification Method:
Affinity purification
Gene ID:
2986
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse eye, using GUCY2F Rabbit pAb (CAB14242) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
