The GUCY2C Polyclonal Antibody (CAB10562) is a valuable tool for researchers studying GUCY2C, a receptor protein involved in regulating gastrointestinal function and tumorigenesis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in various applications, including Western blotting.GUCY2C, also known as guanylate cyclase 2C, is a transmembrane receptor expressed in the gastrointestinal tract and implicated in signaling pathways that control intestinal fluid balance and cell growth. Dysregulation of GUCY2C has been linked to colorectal cancer and other GI disorders, making it a promising target for therapeutic interventions.
By specifically binding to the GUCY2C protein, this antibody enables researchers to detect and analyze its expression levels in different cell types and tissues. This makes it an essential tool for investigations in oncology, gastroenterology, and other fields where GUCY2C signaling pathways play a role.Understanding the role of GUCY2C in gastrointestinal health and disease can provide insights into potential treatment strategies and personalized medicine approaches for patients with conditions linked to GUCY2C dysfunction. The GUCY2C Polyclonal Antibody is a valuable resource for scientists aiming to unravel the complexities of this important receptor protein.
Product Name:
GUCY2C Rabbit Polyclonal Antibody
SKU:
CAB10562
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-330 of human GUCY2C (NP_004954.2).
Cell membrane, Endoplasmic reticulum membrane, Single-pass type I membrane protein.
Calculated MW:
123kDa
Observed MW:
123kDa
This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive).
Purification Method:
Affinity purification
Gene ID:
2984
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GUCY2C antibody (CAB10562) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
