The GUCY1B3 Polyclonal Antibody (CAB15276) is a powerful tool for researchers studying GUCY1B3, a key enzyme involved in the production of cyclic GMP (cGMP) signaling molecules. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the GUCY1B3 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology, pharmacology, and cardiovascular research.GUCY1B3 is an important regulator of cGMP signaling pathways, which play a crucial role in various physiological processes such as smooth muscle relaxation, platelet aggregation, and vasodilation.
Dysregulation of cGMP signaling has been implicated in a range of diseases including hypertension, erectile dysfunction, and heart failure. By understanding the function of GUCY1B3, researchers can gain valuable insights into the development and treatment of these conditions.Overall, the GUCY1B3 Polyclonal Antibody (CAB15276) is a valuable tool for investigating the role of GUCY1B3 in physiological and pathological processes, opening up new possibilities for therapeutic interventions targeting cGMP signaling pathways.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human Guanylyl Cyclase beta 1 (Guanylyl Cyclase beta 1 (GUCY1B3)) (NP_000848.1).
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2983
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Guanylyl Cyclase beta 1 (GUCY1B3) Rabbit pAb (CAB15276) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30S.
