The GUCY1A3 Polyclonal Antibody (CAB12710) is a valuable tool for research involving GUCY1A3, a key enzyme involved in the regulation of cyclic GMP (cGMP) levels in cells. This antibody is raised in rabbits and has been extensively validated for use in various applications, including Western blot and immunofluorescence.GUCY1A3 plays a crucial role in mediating various physiological processes, including smooth muscle relaxation, neurotransmission, and vasodilation. Dysregulation of GUCY1A3 has been implicated in several diseases, such as cardiovascular disorders, erectile dysfunction, and neurological conditions. Therefore, studying the expression and activity of GUCY1A3 is essential for understanding its role in health and disease.
This polyclonal antibody specifically targets the GUCY1A3 protein, allowing for reliable detection and quantification in different experimental setups. It is highly recommended for use in molecular biology and pharmacological studies focused on cyclic nucleotide signaling pathways and related disorders. By utilizing this antibody, researchers can gain valuable insights into the mechanisms underlying cGMP-mediated signaling and potentially identify new therapeutic targets for a range of medical conditions.
Product Name:
GUCY1A3 Rabbit Polyclonal Antibody
SKU:
CAB12710
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GUCY1A3 (NP_000847.2).
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2982
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GUCY1A3 Rabbit pAb (CAB12710) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
