The GUCA2B Polyclonal Antibody (CAB8390) is a valuable tool for research involving GUCA2B, a protein involved in calcium regulation and signaling in the intestine. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in various applications such as Western blot and immunohistochemistry.GUCA2B, also known as guanylin, is a peptide hormone that plays a crucial role in regulating fluid and electrolyte balance in the intestine. Its function in the gastrointestinal tract makes it a key player in conditions like electrolyte imbalance, diarrhea, and intestinal diseases.
Research on GUCA2B can provide insights into these conditions and lead to potential therapeutic interventions.The GUCA2B Polyclonal Antibody allows for the detection and analysis of GUCA2B protein expression in different cell types and tissues, making it a versatile tool for studies in gastroenterology and endocrinology. By understanding the role of GUCA2B in intestinal physiology, researchers can further explore its potential as a target for treating digestive disorders and improving gastrointestinal health.
Product Name:
GUCA2B Rabbit Polyclonal Antibody
SKU:
CAB8390
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GUCA2B (NP_009033.1).
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys.
Purification Method:
Affinity purification
Gene ID:
2981
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse small intestine, using GUCA2B antibody (CAB8390) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
