The GUCA1B Polyclonal Antibody (CAB14739) is a valuable tool for researchers studying GUCA1B, a protein involved in calcium signaling pathways in the retina and brain. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the GUCA1B protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an ideal choice for studies focusing on vision and neurological disorders.
GUCA1B, also known as guanylate cyclase-activating protein 1, plays a crucial role in regulating the sensitivity of photoreceptor cells to light stimuli. Its involvement in calcium signaling pathways in the retina underscores its importance in visual function and highlights its potential as a therapeutic target for retinal diseases. Understanding the role of GUCA1B in these processes is essential for advancing our knowledge of vision disorders and developing innovative treatment strategies for patients.
Product Name:
GUCA1B Rabbit Polyclonal Antibody
SKU:
CAB14739
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GUCA1B (NP_002089.4).
The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa.
Purification Method:
Affinity purification
Gene ID:
2979
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GUCA1B Rabbit pAb (CAB14739) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
