The GTSE1 Polyclonal Antibody (CAB13903) is a valuable tool for researchers studying GTSE1, a protein involved in regulating cell cycle progression and microtubule dynamics. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By binding specifically to the GTSE1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell biology and cancer research.GTSE1, also known as B99, plays a crucial role in cell division by ensuring proper spindle formation and chromosome segregation.
Dysregulation of GTSE1 has been implicated in various types of cancer, making it a promising target for cancer therapeutics. Understanding the function of GTSE1 is essential for devising strategies to target this protein in cancer cells and potentially improve cancer treatment outcomes.Overall, the GTSE1 Polyclonal Antibody is a powerful tool for researchers looking to delve deeper into the mechanisms governing cell division and identify potential therapeutic targets for cancer treatment. Its specificity and reliability make it an indispensable asset for advancing research in cell biology and oncology.
Product Name:
GTSE1 Rabbit Polyclonal Antibody
SKU:
CAB13903
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human GTSE1 (NP_057510.4).
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.
Purification Method:
Affinity purification
Gene ID:
51512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GTSE1 Rabbit pAb (CAB13903) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
