The GTPase HRAS Rabbit Monoclonal Antibody (CAB19619) is a valuable tool for researchers studying the HRAS protein, which is involved in various cellular processes such as cell growth, differentiation, and survival. This antibody, generated in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. It binds specifically to the HRAS protein, allowing for accurate detection and analysis in a variety of cell types.The HRAS protein, a member of the RAS family of small GTPases, plays a crucial role in signaling pathways that regulate cell growth and proliferation. Dysregulation of HRAS is associated with various diseases, including cancer, making it a promising target for therapeutic interventions.
Understanding the function and regulation of HRAS is essential for developing targeted treatments for HRAS-related disorders.Researchers in the fields of cell biology, oncology, and drug development will benefit from the high specificity and sensitivity of the GTPase HRAS Rabbit Monoclonal Antibody (CAB19619) in their studies. By accurately detecting and analyzing HRAS protein levels, this antibody provides valuable insights into the mechanisms underlying cell signaling pathways and disease development.
Product Name:
HRAS Rabbit Monoclonal Antibody
SKU:
CAB19619
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 90-189 of human HRAS (P01112).
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
3265
Clone Number:
ARC0098
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using HRAS Rabbit mAb (CAB19619) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
