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HRAS Rabbit Polyclonal Antibody (CAB7901)

SKU:
CAB7901
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 11 Anti-HRas Antibody CAB7901
  • Cell Biology Antibodies 11 Anti-HRas Antibody CAB7901
  • Cell Biology Antibodies 11 Anti-HRas Antibody CAB7901
€139 - €419
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Description

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HRAS Rabbit Polyclonal Antibody (CAB7901)

The GTPase HRAS Polyclonal Antibody (CAB7901) is a vital tool for research involving the HRAS protein, a member of the Ras family of GTPases known for its role in cell signaling pathways and oncogenesis. This polyclonal antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples, making it suitable for Western blot applications.HRAS is a key regulator of cell proliferation, differentiation, and survival, making it a crucial target for studies in cancer research and developmental biology. The GTPase HRAS Polyclonal Antibody facilitates the detection and analysis of HRAS protein levels in various cell types, enabling researchers to investigate the role of HRAS in tumorigenesis and other cellular processes.

By understanding the function and regulation of HRAS, researchers can gain insight into the molecular mechanisms underlying cancer progression and potentially identify novel therapeutic targets for cancer treatment. The GTPase HRAS Polyclonal Antibody is an essential tool for advancing our understanding of HRAS biology and its implications in disease pathology.

Product Name:HRAS Rabbit Polyclonal Antibody
SKU:CAB7901
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HRAS (NP_203524.1).
Sequence:MTEY KLVV VGAG GVGK SALT IQLI QNHF VDEY DPTI EDSY RKQV VIDG ETCL LDIL DTAG QEEY SAMR DQYM RTGE GFLC VFAI NNTK SFED IHHY REQI
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1; HRAS
Positive Sample:SKOV3,Mouse brain,Mouse skeletal muscle,Mouse kidney,Rat brain
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasm, Cytoplasmic side, Golgi apparatus, Golgi apparatus membrane, Lipid-anchor, Lipid-anchor, Nucleus, perinuclear region.
Calculated MW:21kDa
Observed MW:21kDa

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Purification Method:Affinity purification
Gene ID:3265
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using HRAS Rabbit pAb (CAB7901) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 20s.

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