null

GTF3C5 Antibody (PACO57596)

SKU:
PACO57596
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

system_update_altDatasheetsystem_update_altMSDS

GTF3C5 Antibody (PACO57596)

The GTF3C5 Polyclonal Antibody (PACO57596) is a valuable tool for researchers studying the transcription factor GTF3C5, which plays a crucial role in RNA polymerase III transcription. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blot applications.GTF3C5 is essential for the initiation of transcription of genes encoding small structural RNAs, such as tRNAs and 5S rRNA. Dysregulation of RNA polymerase III transcription has been linked to various diseases, including cancer and neurological disorders, highlighting the importance of studying the role of GTF3C5 in these contexts.

By utilizing the GTF3C5 Polyclonal Antibody, researchers can investigate the expression levels and localization of GTF3C5 in different cell types and tissues, providing valuable insights into its function and potential implications in disease. This antibody is a valuable tool for advancing our understanding of the molecular mechanisms underlying RNA polymerase III transcription and its role in health and disease.

Antibody Name:GTF3C5 Antibody (PACO57596)
Antibody SKU:PACO57596
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:Human
Immunogen:Recombinant Human General transcription factor 3C polypeptide 5 protein (305-448AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageIHC image of PACO57596 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
Synonyms:General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon), GTF3C5
UniProt Protein Function:GTF3C5: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. Belongs to the TFIIIC subunit 5 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; Transcription initiation complexChromosomal Location of Human Ortholog: 9q34Cellular Component: nucleoplasm; transcription factor TFIIIC complexMolecular Function: DNA binding; protein bindingBiological Process: 5S class rRNA transcription; transcription from RNA polymerase III promoter; transcription, DNA-dependent; tRNA transcription from RNA polymerase III promoter
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9Y5Q8
NCBI GenInfo Identifier:47606222
NCBI Gene ID:9328
NCBI Accession:Q9Y5Q8.2
UniProt Secondary Accession:Q9Y5Q8,Q5T7U2, Q5T7U3, Q8N2U7, Q8N857, Q96GD9, Q9H4P2 A6NI44, A6NJB9
UniProt Related Accession:Q9Y5Q8
Molecular Weight:60,369 Da
NCBI Full Name:General transcription factor 3C polypeptide 5
NCBI Synonym Full Names:general transcription factor IIIC subunit 5
NCBI Official Symbol:GTF3C5  
NCBI Official Synonym Symbols:TFIIIC63; TFiiiC2-63; TFIIICepsilon  
NCBI Protein Information:general transcription factor 3C polypeptide 5
UniProt Protein Name:General transcription factor 3C polypeptide 5
UniProt Synonym Protein Names:TF3C-epsilon; Transcription factor IIIC 63 kDa subunit; TFIIIC 63 kDa subunit; TFIIIC63; Transcription factor IIIC subunit epsilon
Protein Family:General transcription factor 3C polypeptide
UniProt Gene Name:GTF3C5  
UniProt Entry Name:TF3C5_HUMAN
Antibodies
GTF3C5 Antibody (PACO09637)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

Related Products