The GTF3C5 Polyclonal Antibody (PACO09637) is a valuable tool for researchers studying GTF3C5, a key factor involved in transcription initiation and regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the GTF3C5 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and gene expression studies.GTF3C5, a crucial component of the transcription machinery, plays a critical role in the initiation of RNA polymerase II transcription and regulation of gene expression.
Its involvement in these processes makes it a promising target for research on various diseases, including cancer and genetic disorders. Understanding the function of GTF3C5 can provide valuable insights into the mechanisms underlying transcriptional control and may lead to the development of novel therapeutic strategies aimed at modulating gene expression patterns.
general transcription factor IIIC, polypeptide 5, 63kDa;GTF3C5;FLJ20857;TFIIIC63;TFIIICepsilon;TFiiiC2-63 ;
UniProt Protein Function:
GTF3C5: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. Belongs to the TFIIIC subunit 5 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; Transcription initiation complexChromosomal Location of Human Ortholog: 9q34Cellular Component: nucleoplasm; transcription factor TFIIIC complexMolecular Function: DNA binding; protein bindingBiological Process: 5S class rRNA transcription; transcription from RNA polymerase III promoter; transcription, DNA-dependent; tRNA transcription from RNA polymerase III promoter
