The GTF3C3 Polyclonal Antibody (CAB18405) is a valuable tool for researchers studying the GTF3C3 protein, an essential component of the RNA polymerase III transcription machinery. This rabbit polyclonal antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the GTF3C3 protein, this antibody enables precise detection and analysis in various cell types, facilitating in-depth research in molecular biology and gene expression regulation.GTF3C3 is a critical factor in the initiation of transcription by RNA polymerase III, playing a key role in the synthesis of small nuclear RNAs and other non-coding RNAs essential for cellular function.
Dysregulation of RNA polymerase III activity has been linked to various diseases, including cancer and neurodevelopmental disorders. By investigating the function of GTF3C3, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
GTF3C3 Rabbit Polyclonal Antibody
SKU:
CAB18405
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human GTF3C3 (NP_036218.1).
The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9330
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GTF3C3 Rabbit pAb (CAB18405) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
