The GTF2IRD1 Polyclonal Antibody is a valuable tool for researchers studying GTF2IRD1, a transcription factor implicated in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the GTF2IRD1 protein, this antibody allows for the detection and analysis of GTF2IRD1 expression in a variety of cell types, making it an essential reagent for studies in molecular biology and genetics.GTF2IRD1, also known as General Transcription Factor 2I Repeat Domain-Containing Protein 1, plays a crucial role in gene regulation and is associated with the development of certain genetic disorders.
Its involvement in transcriptional control makes it a key target for research into diseases such as Williams-Beuren syndrome and other neurodevelopmental conditions. By elucidating the functions of GTF2IRD1, researchers can gain valuable insights into the molecular mechanisms underlying these disorders and pave the way for the development of targeted therapeutics.
Product Name:
GTF2IRD1 Polyclonal Antibody
SKU:
CAB24506
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 660-890 of human GTF2IRD1 (NP_057412.1).
The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
9569
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Rat liver, using GTF2IRD1 Rabbit pAb (CAB24506) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
