The GSX2 Polyclonal Antibody (PACO58781) is a vital tool for researchers studying the GSX2 protein, a transcription factor linked to development processes in the brain, particularly in the forebrain. This antibody, produced using rabbit immunization, shows high specificity for human samples and is proven effective in Western blot analyses. By binding to GSX2, this antibody allows for accurate detection and investigation of this protein in a variety of cell types, making it ideal for research in neuroscience and developmental biology.
GSX2 is known for its role in regulating gene expression during brain development, making it a key player in processes like neurogenesis and patterning. The insights gained from studying GSX2 can provide valuable information on brain development disorders, neurodevelopmental diseases, and even potential therapeutic targets for neurological conditions. With the GSX2 Polyclonal Antibody, researchers can delve deeper into understanding the functions and mechanisms of GSX2, paving the way for advancements in neurobiology research.
Antibody Name:
GSX2 Antibody (PACO58781)
Antibody SKU:
PACO58781
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human GS homeobox 2 protein (15-118AA)
IHC image of PACO58781 diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Transcription factor that binds 5'-CNAATTAG-3' DNA sequence.
GSH2: Probable transcription factor that binds to the DNA sequence 5'-CNAATTAG-3'. Belongs to the Antp homeobox family.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 4q12
